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apalutamide will lower the extent or impact of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs that are CYP3A4 substrates may lead to decreased publicity to these medications.fedratinib will raise the level or influ